Quantum bioprocessing pump

Quantum: Redefining peristaltic technology for bioprocessing

Traditionally, peristaltic pumps have been the pump of choice in low pressure upstream processes including fermentation feed and media transfer. The gentle peristaltic pumping action guarantees low shear, high accuracy and zero cross contamination to uphold cell viability and corresponding high cell densities.

With this knowledge in mind, Watson-Marlow Fluid Technology Group designed and developed Quantum to redefine the use of peristaltic pump technology specifically for downstream bioprocessing.

By adding Quantum’s unique and revolutionary capabilities to the established peristaltic pumping principle—matched with ReNu SU Technology—Quantum is clearly the most logical choice for downstream bioprocessing.

Trace pulsation at 3 bar

The revolutionary performance provided by Quantum extends the frontiers of peristaltic technology, delivering up to 3 bar constant pressure with only trace pulsation of 0.12 bar throughout the flow range.

Ultra-low shear

Quantum matched with its patented ReNu SU Technology cartridge delivers ultra-low shear and accuracy at set speed throughout the cartridge life. The independent test data demonstrates how Quantum delivers low shear and higher process yields by comparing the mean diameter of fragile oil based emulsion particles as they pass through a pump. The particle breakdown is twice as much with the quaternary pump (grey line) as with Quantum (yellow line). Tests were conducted at 12 L/min and 14.5 psi (1 bar) pressure.

The data presented in the above two graphs was provided by an independent third-party source

Designed specifically for downstream

Quantum delivers flow linearity throughout the pressure range. With a 4,000:1 control ratio, operators can sustain constant transmembrane pressure in micro/ultrafiltration.

The Quantum pump

• Quantum has been designed and built specifically for bioprocessing. The paint free housing is IP66 (NEMA 12/13) rated with industry standard power and interface connections.
• Quantum offers analog remote control functionality, common to all Watson-Marlow Fluid Technology Group cased pumps avoiding the need for operator retraining.
• Quantum’s user interface is uniquely positioned at the front of the pump enabling visual confirmation of operating state and access to operation controls even when skid mounted.
• Quantum is fully certified to CE, UL and IEC61010-1 electrical safety standards.

Make sterile connections in non-sterile environments

Plug and play with our ReNu SU (single-use) Technology cartridge assemblies, provided with aseptic connectors and sterility assurance claim.

ReNu SU Technology cartridge

Sterile ReNu SU Technology cartridge

Sterile ReNu SU Technology cartridge assemblies guarantee quick and secure fluid path connections. These products are released based on a VDmax25 study as detailed by ANSI/AAMI/ISO 11137 guidelines, to provide a sterility assurance level (SAL) of 10^-6 when irradiated to a minimum of 25 kGY.

Standard ReNu SU cartridge assemblies include a range of aseptic connectors which enable sterile connections to be made in controlled non-classified spaces.

• Options of industry recognised aseptic connectors from CPC, PALL and GE
• ISO Class 7 cleanroom manufactured and packaged assemblies with lot traceability on every component

Quantum successfully combines application specific pump capabilities with single-use fluid path components such as the ground breaking ReNu SU Technology cartridge, the popular BioPure range of barbs, clamps, gaskets and high pressure braided hose. For the first time, this integrated approach allows a considerable reduction in cost and time of pump validation prior to being specified into single-use systems (SUS).

ReNu SU Technology cartridges are fully manufactured in ISO Class 7 cleanrooms and are suitable for gamma irradiation at up to 50kGy. ReNu SU Technology cartridges are supplied with an industry-leading validation guide. The guide includes a comprehensive set of biocompatibility data with material tests such as USP88, Class VI (in vivo) and USP87 (in vitro). Detailed extractable testing with a range of solvents in line with BPOG and BPSA guidelines has also been undertaken. The validation guide supports your validation process, reducing your overall time to market.

The secure and consistent positioning of the ReNu SU Technology cartridge in the pumphead—clamped firmly in place at its manifolds—guarantees a secure connection every time. Additionally each cartridge is supplied with a quick change kit comprising of clamps, gaskets and end caps all designed to keep the time it takes to replace a cartridge to a minimum.

Connection kits are also available consisting of braid reinforced silicone hose configured to customers’ requirements with BioBarb fittings. All components are manufactured in ISO Class 7 cleanrooms.

Single-use fluid path

The synergy between peristaltic pumps and single-use pump systems cannot be overstated. The ReNu SU Technology cartridge slides effortlessly into position allowing for a change of fluid path in minutes whilst eliminating alignment errors.